The primary reason behind the variability of effects of the different strains and vein colors of kratom is the disparity in the balance of kratom alkaloids. The leaves contain numerous types of alkaloids that are naturally capable of delivering effective and distinctive medicinal properties.
The following is a concise list of the most popular kratom alkaloids, along with accurate information about their specific characteristics, concentration, and composition in relation to their mass:
Mitragynine – an effective pain mediator (as an active agonist opiod receptor). Also functions as an antidiarrheal, antitussive, anti-malarial, adrenergic and a moderate stimulant (45-75 percent). The MOR potency of this alkaloid is one-hundredth that of morphine. *minimum recorded concentration of the content material is 12 percent*
7-Hydroxymitragynine (7-HMG) – works primarily as an analgesic (active agonist opiod receptor). Also works well as an antitussive and antidiarrheal (1.5 to 2.5 percent). The MOR potency of this alkaloid is one tenth that of morphine.
Mitraphylline – a mainstream muscle relaxant. It also works actively as an antihypertensive, anti-leukemic, anti-amnesic, vasodilator, and a subsidiary stimulant of the immune system (1 percent or less)
Corynantheidine – as a subsidiary antagonist opiod receptor (1% or less)
Ciliaphylline – an effective analgesic and antitussive (1 percent or less)
Corynoxine A – an active dopamine stabilizer (1 percent or less)
Corynoxine B – as a subsidiary dopamine stabilizer, it helps in augmenting the effects delivered by Corynoxine A (1 percent or less)
Epicatechin – works best as an antioxidant, antiviral, anti-inflammatory, anti-diabetic, anti-mutagenic, and anti-leukemic (1percent or less) *an important alkaloid also found in green tea leaf*
Ajmalicine – functions mainly as an anti-aggregant, anti-adrenergic, and as a cerebrocirculant. In addition, it provides moderate efficacy as an anti-convulsant, muscle relaxant, and sedative (1 percent or less)
Isomitraphylline – as a primary stimulant of the immune system (1 percent or less concentration of the total composition)
Isomitrafoline – as an auxiliary stimulant of the immune system (1% or less)
Isorhynchophylline – as a mainstream stimulant of the immune system (1 percent or less)
Isopteropodine – an active stimulant of the immune system (1% or less)
Rhynchophylline – a proficient anti-inflammatory, antihypertensive, and vasodilator (1 percent or less)
Speciogynine – as an active muscle relaxant (6.5 to 7.5 percent)
Speciophylline – a powerful anti-leukemic (1 percent or less)
Speciociliatine – a moderate antagonist opiod receptor (1 percent or less)
Tetrahydroalstonine – an effective anti-adrenergic and blood sugar stabilizer (1 percent or less)
Hydroxycorynantheidine – works efficiently as a secondary active analgesic (1 percent or less) *In the presence of 7-Hydroxymitragynine it helps in augmenting the effects of pain relief thoroughly*
Akuammigine – inactivated (1 percent or less)
Speciofoline – inactivated (1 percent or less)
Stipulatine – inactivated (1 percent or less)
Mitrafoline – inactivated (1percent or less)
Mitraversine – inactivated (1percent or less)
Note that the values of the concentration percentages are based on average derivative research data. As such, they are not represented to be absolute.
The alkaloids in kratom leaves ultimately indicate the level of potency and the effects they can deliver effectively.
Many researchers in the past, in the light of their comprehensive assessments and studies, concluded that the specification profiles of the alkaloids differ considerably from the various types of strains and vein color. The reason behind this is that every strain or vein color possesses a unique alkaloid balance that varies on the type and efficacy of the therapeutic traits they offer.
For instance, the Malaysian strains contain a higher concentration of 7-hydroxymitragynine which makes them more potent as analgesics.
Conversely, the Thai strain possesses a higher concentration of Mitragynine which allows it to provide other medicinal effects including pain relief, but at a different rate of responsiveness and level of potency.
Studies and researches about the kinds of alkaloids found in the different strains and vein color types of kratom are constantly evolving. There is a lot more to be learned about their remarkable medicinal properties.